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A Map of the Cat?

In the Graduate College dining room at Princeton everybody used to sit with his own group. I sat with the physicists, but after a bit I thought: It would be nice to see what the rest of the world is doing, so Ill sit for a week or two in each of the other groups.

When I sat with the philosophers I listened to them discuss very seriously a book called Process and Reality by Whitehead. They were using words in a funny way, and I couldnt quite understand what they were saying. Now I didnt want to interrupt them in their own conversation and keep asking them to explain something, and on the few occasions that I did, theyd try to explain it to me, but I still didnt get it. Finally they invited me to come to their seminar.

They had a seminar that was like, a class. It had been meeting once a week to discuss a new chapter out of Process and Realitysome guy would give a report on it and then there would be a discussion. I went to this seminar promising myself to keep my mouth shut, reminding myself that I didnt know anything about the subject, and I was going there just to watch.

What happened there was typicalso typical that it was unbelievable, but true. First of all, I sat there without saying anything, which is almost unbelievable, but also true. A student gave a report on the chapter to be studied that week. In it Whitehead kept using the words essential object in a particular technical way that presumably he had defined, but that I didnt understand.

After some discussion as to what essential object meant, the professor leading the seminar said something meant to clarify things and drew something that looked like lightning bolts on the blackboard. Mr. Feynman, he said, would you say an electron is an essential object?

Well, now I was in trouble. I admitted that I hadnt read the book, so I had no idea of what Whitehead meant by the phrase; I had only come to watch. But, I said, Ill try to answer the professors question if you will first answer a question from me, so I can have a better idea of what essential object means. Is a brick an essential object?

What I had intended to do was to find out whether they thought theoretical constructs were essential objects. The electron is a theory that we use; it is so useful in understanding the way nature works that we can almost call it real. I wanted to make the idea of a theory clear by analogy. In the case of the brick, my next question was going to be, What about the inside of the brick?and I would then point out that no one has ever seen the inside of a brick. Every time you break the brick, you only see the surface. That the brick has an inside is a simple theory which helps us understand things better. The theory of electrons is analogous. So I began by asking, Is a brick an essential object?

Then the answers came out. One man stood up and said, A brick as an individual, specific brick. That is what Whitehead means by an essential object.

Another man said, No, it isnt the individual brick that is an essential object; its the general character that all bricks have in commontheir brickinessthat is the essential object.

Another guy got up and said, No, its not in the bricks themselves. Essential object means the idea in the mind that you get when you think of bricks.

Another guy got up, and another, and I tell you I have never heard such ingenious different ways of looking at a brick before. And, just like it should in all stories about philosophers, it ended up in complete chaos. In all their previous discussions they hadnt even asked themselves whether such a simple object as a brick, much less an electron, is an essential object.

After that I went around to the biology table at dinner time. I had always had some interest in biology, and the guys talked about very interesting things. Some of them invited me to come to a course they were going to have in cell physiology. I knew something about biology, but this was a graduate course. Do you think I can handle it? Will the professor let me in? I asked.

They asked the instructor, E. Newton Harvey, who had done a lot of research on light-producing bacteria. Harvey said I could join this special, advanced course provided one thingthat I would do all the work, and report on papers just like everybody else.

Before the first class meeting, the guys who had invited me to take the course wanted to show me some things under the microscope. They had some plant cells in there, and you could see some little green spots called chloroplasts (they make sugar when light shines on them) circulating around. I looked at them and then looked up: How do they circulate? What pushes them around? I asked.

Nobody knew. It turned out that it was not understood at that time. So right away I found out something about biology: it was very easy to find a question that was very interesting, and that nobody knew the answer to. In physics you had to go a little deeper before you could find an interesting question that people didnt know.

When the course began, Harvey started out by drawing a great, big picture of a cell on the blackboard and labeling all the things that are in a cell. He then talked about them, and I understood most of what he said.

After the lecture, the guy who had invited me said, Well, how did you like it?

Just fine, I said. The only part I didnt understand was the part about lecithin. What is lecithin?

The guy begins to explain in a monotonous voice: All living creatures, both plant and animal, are made of little bricklike objects called cells.

Listen, I said, impatiently, I know all that; otherwise I wouldnt be in the course. What is lecithin?

I dont know.

I had to report on papers along with everyone else, and the first one I was assigned was on the effect of pressure on cellsHarvey chose that topic for me because it had something that had to do with physics. Although I understood what I was doing, I mispronounced everything when I read my paper, and the class was always laughing hysterically when Id talk about blastospheres instead of blastomeres, or some other such thing.

The next paper selected for me was by Adrian and Bronk. They demonstrated that nerve impulses were sharp, single-pulse phenomena. They had done experiments with cats in which they had measured voltages on nerves.

I began to read the paper. It kept talking about extensors and flexors, the gastrocnemius muscle, and so on. This and that muscle were named, but I hadnt the foggiest idea of where they were located in relation to the nerves or to the cat. So I went to the librarian in the biology section and asked her if she could find me a map of the cat.

A map of the cat, sir? she asked, horrified. You mean a zoological chart! From then on there were rumors about some dumb biology graduate student who was looking for a map of the cat.

When it came time for me to give my talk on the subject, I started off by drawing an outline of the cat and began to name the various muscles.

The other students in the class interrupt me: We know all that!

Oh, I say, you do? Then no wonder I can catch up with you so fast after youve had four years of biology. They had wasted all their time memorizing stuff like that, when it could be looked up in fifteen minutes.

After the war, every summer I would go traveling by car somewhere in the United States. One year, after I was at Caltech, I thought, This summer, instead of going to a different place, Ill go to a different field.

It was right after Watson and Cricks discovery of the DNA spiral. There were some very good biologists at Caltech because Delbr"uck had his lab there, and Watson came to Caltech to give some lectures on the coding systems of DNA. I went to his lectures and to seminars in the biology department and got full of enthusiasm. It was a very exciting time in biology, and Caltech was a wonderful place to be.

I didnt think I was up to doing actual research in biology, so for my summer visit to the field of biology I thought I would just hang around the biology lab and wash dishes, while I watched what they were doing. I went over to the biology lab to tell them my desire, and Bob Edgar, a young post-doc who was sort of in charge there, said he wouldnt let me do that. He said, Youll have to really do some research, just like a graduate student, and well give you a problem to work on. That suited me fine.

I took a phage course, which told us how to do research with bacteriophages (a phage is a virus that contains DNA and attacks bacteria). Right away I found that I was saved a lot of trouble because I knew some physics and mathematics. I knew how atoms worked in liquids, so there was nothing mysterious about how the centrifuge worked. I knew enough statistics to understand the statistical errors in counting little spots in a dish. So while all the biology guys were trying to understand these new things, I could spend my time learning the biology part.

There was one useful lab technique I learned in that course which I still use today. They taught us how to hold a test tube and take its cap off with one hand (you use your middle and index fingers), while leaving the other hand free to do something else (like hold a pipette that youre sucking cyanide up into). Now, I can hold my toothbrush in one hand, and with the other hand, hold the tube of toothpaste, twist the cap off, and put it back on.

It had been discovered that phages could have mutations which would affect their ability to attack bacteria, and we were supposed to study those mutations. There were also some phages that would have a second mutation which would reconstitute their ability to attack bacteria. Some phages which mutated back were exactly the same as they were before. Others were not: There was a slight difference in their effect on bacteriathey would act faster or slower than normal, and the bacteria would grow slower or faster than normal. In other words, there were back mutations, but they werent always perfect; sometimes the phage would recover only part of the ability it had lost.

Bob Edgar suggested that I do an experiment which would try to find out if the back mutations occurred in the same place on the DNA spiral. With great care and a lot of tedious work I was able to find three examples of back mutations which had occurred very close togethercloser than anything they had ever seen so farand which partially restored the phages ability to function. It was a slow job. It was sort of accidental: You had to wait around until von got a double mutation, which was very rare.

I kept trying to think of ways to make a phage mutate more often and how to detect mutations more quickly, but before I could come up with a good technique the summer was over, and I didnt feel like continuing on that problem.

However, my sabbatical year was coming up, so I decided to work in the same biology lab but on a different subject. I worked with Matt Meselson to some extent, and then with a nice fella from England named J. D. Smith. The problem had to do with ribosomes, the machinery in the cell that makes protein from what we now call messenger RNA. Using radioactive substances, we demonstrated that the RNA could come out of ribosomes and could be put back in.

I did a very careful job in measuring and trying to control everything, but it took me eight months to realize that there was one step that was sloppy. In preparing the bacteria, to get the ribosomes out, in those days you ground it up with alumina in a mortar. Everything else was chemical and all under control, but you could never repeat the way you pushed the pestle around when you were grinding the bacteria. So nothing ever came of the experiment.

Then I guess I have to tell about the time I tried with Hildegarde Lamfrom to discover whether peas could use the same ribosomes as bacteria. The question was whether the ribosomes of bacteria can manufacture the proteins of humans or other organisms, She had just developed a scheme for getting the ribosomes out of peas and giving them messenger RNA so that they would make pea proteins. We realized that a very dramatic and important question was whether ribosomes from bacteria, when given the peas messenger RNA, would make pea protein or bacteria protein. It was to be a very dramatic and fundamental experiment.

Hildegarde said, Ill need a lot of ribosomes from bacteria.

Meselson and I had extracted enormous quantities of ribosomes from E. coli for some other experiment. I said, Hell, Ill just give you the ribosomes weve got. We have plenty of them in my refrigerator at the lab.

It would have been a fantastic and vital discovery if I had been a good biologist. But I wasnt a good biologist. We had a good idea, a good experiment, the right equipment, but I screwed it up: I gave her infected ribosomesthe grossest possible error that you could make in an experiment like that. My ribosomes had been in the refrigerator for almost a month, and had become contaminated with some other living things. Had I prepared those ribosomes promptly over again and given them to her in a serious and careful way, with everything under control, that experiment would have worked, and we would have been the first to demonstrate the uniformity of life: the machinery of making proteins, the ribosomes, is the same in every creature. We were there at the right place, we were doing the right things, but I was doing things as an amateurstupid and sloppy.

You know what it reminds me of? The husband of Madame Bovary in Flauberts book, a dull country doctor who had some idea of how to fix club feet, and all he did was screw people up. I was similar to that unpracticed surgeon.

The other work on the phage I never wrote upEdgar kept asking me to write it up, but I never got around to it. Thats the trouble with not being in your own field: You dont take it seriously.

I did write something informally on it. I sent it to Edgar, who laughed when he read it. It wasnt in the standard form that biologists usefirst, procedures, and so forth. I spent a lot of time explaining things that all the biologists knew. Edgar made a shortened version, but I couldnt understand it. I dont think they ever published it. I never published it directly.

Watson thought the stuff I had done with phages was of some interest, so he invited me to go to Harvard. I gave a talk to the biology department about the double mutations which occurred so close together. I told them my guess was that one mutation made a change in the protein, such as changing the pH of an amino acid, while the other mutation made the opposite change on a different amino acid in the same protein, so that it partially balanced the first imitationnot perfectly, but enough to let the phage operate again. I thought they were two changes in the same protein, which chemically compensated each other.

That turned out not to be the case. It was found out a few years later by people who undoubtedly developed a technique for producing and detecting the mutations faster, that what happened was, the first mutation was a mutation in which an entire DNA base was missing. Now the code was shifted and could not be read any more. The second mutation was either one in which an extra base was put back in, or two more were taken out. Now the code could be read again. The closer the second mutation occurred to the first, the less message would be altered by the double mutation, and the more completely the phage would recover its lost abilities. The fact that there are three letters to code each amino acid was thus demonstrated.

While I was at Harvard that week, Watson suggested something and we did an experiment together for a few days. It was an incomplete experiment, but I learned some new lab techniques from one of the best men in the field.

But that was my big moment: I gave a seminar in the biology department of Harvard! I always do that, get into something and see how far I can go.

I learned a lot of things in biology, and I gained a lot of experience. I got better at pronouncing the words, knowing what not to include in a paper or a seminar, and detecting a weak technique in an experiment. But I love physics, and I love to go back to it.


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